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KMID : 0360419770130020035
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Korean Journal of Pharmacology
1977 Volume.13 No. 2 p.35 ~ p.39
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Influence of Intraventricular cAMP on the Renal Function of the Rabbit
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Abstract
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Cyclic adenosine monophosphate (cAMP), known as a versatile regulator of cellular processes and as a secondary messenger of various hormones and other biogenic agents, such as prostaglandins and histamine, induced prompt and transient antidiuresis followed by mild natriuresis and diuresis, when it was administered into the lateral of ventricle of the rabbit in doses ranging from 100 ㎍ to 1 mg. The initial antidiuresis was brought about by the systemic hypotension, whereas the secondary diuresis seemed to be resulted from the decreased tubular reabsorption of sodium, suggestive of participation of certain endogenous natriuretic agent. This observation suggests that cAMP might be involoved in the center-mediated renal action of prostaglandins.
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